Clinical trials for osteoarthritis of the knee. Jan 27, 2016 · Thus, oral HA can relieve knee pain.
Osteoarthritis (OA) is the most common form of arthritis and one of the leading causes of disability. This study was a prospective, randomized, double-blind, controlled clinical trial. Objective: Osteoarthritis is a degenerative disease of the joints. Up to 18 patients ages 50 to 75 will be enrolled in the phase 1/2a clinical trial to test IMM01-STEM, a stem-cell-derived treatment developed by Immunis Inc. Volunteers eligible to take part in a clinical trial will receive: Complementary health assessment, including Blood Cholesterol check, Mar 19, 2019 · Patients and methods: Data from phase III placebo-controlled clinical trials of patients with moderate-to-severe OA of the knee or hip were pooled to evaluate tanezumab efficacy (four trials) and safety (nine trials). Mesenchymal stromal cell (MSC)-based therapy has been explored as a new regenerative treatment Nov 2, 2023 · The study was a phase 2/3, four-arm parallel, multicenter, single-blind, randomized, controlled clinical trial with 480 patients with a diagnosis of knee osteoarthritis (Kellgren–Lawrence II–IV). 2009. It is characterized by progressive destruction of articular cartilage and the development of chronic pain and constitutes a considerable The ACTiVION-I clinical trial currently has multiple doctors across the US now accepting participants to help identify a new potential treatment for people suffering with knee pain from mild to moderate osteoarthritis of the knee. Aug 11, 2022 · Often knee pain comes from the progressive wear and tear of cartilage known as osteoarthritis, which affects nearly one in six adults -- 867 million people-- worldwide. Apr 19, 2024 · We have read this clinical trial by Yeung et al [1] on self-administered acupressure (SAA) for probable knee osteoarthritis with great interest. This degenerative and progressive joint disease affects around 250 million people worldwide 2 and more than 27 million people in the United States. Underlying m … Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial Oct 9, 2009 · The present clinical trial evaluated the safety and efficacy of UC-II as compared to a combination of glucosamine and chondroitin (G+C) in the treatment of OA of the knee. Registered 13 October 2011. A multi-centre randomized, double-blind, parallel-group clinical trial was carried out in 63 patients with osteoarthritis of the knee to compare the efficacy and tolerability of a course of intra-articular injections of 20 mg sodium hyaluronate with a similar course of injections of placebo. Raychaudhuri 5, 6,. Dev. In China, self acupoint stimulation is used by hundreds of people for home health care. Patients received intravenous tanezumab, tanezumab plus an oral NSAID (naproxen, celecoxib, or diclofenac), active comparator Mar 19, 2019 · Patients and methods: Data from phase III placebo-controlled clinical trials of patients with moderate-to-severe OA of the knee or hip were pooled to evaluate tanezumab efficacy (four trials) and safety (nine trials). The results indicate that UC-II treatment was more efficacious resulting in a significant reduction in all assessments from the baseline at 90 days; whereas, this effect was Objective: Examine effects of whole-body massage on knee osteoarthritis, compared to active control (light-touch) and usual care. This meta-analysis is expected to provide evidence of the efficacy of stem cell therapy, which is currently controversial, as a conservative treatment for knee osteoarthritis. Key findings: Although widely used, the benefits and risks of ibuprofen, especially compared with other non-steroidal anti-inflammatory drugs (NSAIDs) and placebo, have only recently been evaluated in OA of the hip and knee in randomized-controlled clinical trials (RCT). . Aug 2, 2024 · - Radiographic disease: K&L grade 2 or 3 knee osteoarthritis in the target knee, confirmed by X-ray at screening. S. 10. Nov 30, 2021 · Osteoarthritis (OA) is the most common form of arthritis. Patients received intravenous tanezumab, tanezumab plus an oral NSAID (naproxen, celecoxib, or diclofenac), active comparator (naproxen, celecoxib, diclofenac, or oxycodone), or Feb 16, 2018 · This review included 44 prospective clinical trial investigating the feasibility and efficacy of HA injection for knee, hip, and ankle osteoarthritis. et al. The Multicenter Osteoarthritis Study (MOST) This is a longitudinal observational study of the effects of biomechanical, bone and joint structural, and nutritional factors on the incidence and progression of knee symptoms and radiographic and symptomatic knee osteoarthritis (OA). Hum. The most commonly affected joint is the knee and characterized by progressive destruction of articular cartilage, loss of extracellular matrix, and progressive inflammation. It is most common in the elderly. 249 [ PubMed ] [ CrossRef ] [ Google Scholar ] Oct 7, 2023 · Purpose Mesenchymal stem cells (MSCs) present a valuable treatment option for knee osteoarthritis with promising results. 2017. 2018; 16:213. 29 ( 1 ), 48–59. MSCs derived from bone marrow, adipose, and umbilical tissue have the capacity for self-renewal Aug 25, 2023 · Comparative efficacy of intra-articular injection, physical therapy, and combined treatments on pain, function, and sarcopenia indices in knee osteoarthritis: A network meta-analysis of randomized controlled trials. After 3 and 6 weeks, significant decreases in median total scores on the Western Ontario and McMas … Jan 6, 2021 · Knee osteoarthritis is highly prevalent among older adults. Secondary osteoarthritis is the consequence Feb 21, 2020 · Moore RA, Moore OA, Derry S, Peloso PM, Gammaitoni AR, Wang H. This review will take a closer look at hyaluronic acid and its properties, as well clinical effectiveness and future options. However, their use is limited due to complications, such as gastrointestinal bleeding. 49 They Aug 25, 2023 · Clinical examination, ultrasound assessment and aspiration of knee effusion in primary knee osteoarthritis patients. Clin. Design: Multisite RCT assessing the efficacy of massage compared to light-touch and usual care in adults with knee osteoarthritis, with assessments at baseline and weeks 8, 16, 24, 36, and 52. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] May 18, 2013 · Treatment of Osteoarthritis of the Knee – 2nd Edition may be variability between patients in practice and those who participate in clinical trials. The two alignment techniques are Kinematic Alignment (KA) and Mechanical Alignment (MA). May 4, 2020 · After the first promising clinical tests using anti-NGF antibodies, the FDA stopped ongoing trials owing to reports of serious adverse side effects with fast progression of OA and increased demand for knee replacement surgery. 3) years of age with knee OA according to the American College of Rheumatology clinical criteria for OA of the knee and with radiographic confirmed knee OA were enrolled in the study and randomly assigned into 2 groups: One received MSM in doses of 1. E. Apr 15, 2021 · A multicenter, double-blind, phase III clinical trial to evaluate the efficacy and safety of a cell and gene therapy in knee osteoarthritis patients. Jan 10, 2022 · Osteoarthritis, as a degenerative disease, is a common problem and results in high socioeconomic costs and rates of disability. The benefits and safety of MSM in managing OA and long-term use cannot be confirmed from this pilot trial, but its potential clinical application is examined. A Study to Evaluate the Safety and Feasibility of Intra-articular Transplantation of Autologous Adipose Derived Stromal Vascular Fraction (SVF) for Treatment of Osteoarthritis of the Knee Jacksonville, FL. Treatme … Jul 1, 2023 · Purpose of the review This narrative review highlights recent literature pertaining to available intra-articular (IA) therapeutics such as corticosteroids, hyaluronic acid (HA), platelet-rich plasma (PRP), stem cells therapy, and prolotherapy for knee osteoarthritis (OA) by summarizing recently published treatment guidelines and clinical trials, and discusses opinion and future directions Methods: A methodology was developed by an interaction of the Osteoarthritis Research Society International Standing Committee on Clinical Trials, biostatisticians, pharmaceutical company representatives and health agency representatives. 33 Despite numerous treatment approaches, treatments to modify the course of the disease have not reached a threshold of efficacy to gain regulatory approval. Knee osteoarthritis can be divided into two types, primary and secondary. Therefore, it is necessary to find alternative treatments for osteoarthritis. The results indicate that UC-II treatment was more efficacious resulting in a significant reduction in all assessments from the baseline at 90 days; whereas, this effect was not observed in G+C treatment group. Treatments include exercise, weight management, training in self-efficacy and pain-coping skills, and Apr 15, 2021 · A multicenter, double-blind, phase III clinical trial to evaluate the efficacy and safety of a cell and gene therapy in knee osteoarthritis patients. The Arthritis Foundation strives to be leaders in OA research to fulfill the Jan 21, 2020 · To review the current basic science and clinical literature on mesenchymal stem cell (MSC) therapy for articular cartilage defects and osteoarthritis of the knee. Jun 26, 2023 · Knee osteoarthritis (OA), also known as degenerative joint disease, is typically the result of wear and tear and progressive loss of articular cartilage. Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial. We aimed to review the evidence of autologous mesenchymal stem cell therapy on pain, function and severity on imaging in KOA. Crowley , 1 Francis C. Oct 14, 2010 · We randomly assigned 450 patients with osteoarthritis of the knee to receive tanezumab (administered at a dose of 10, 25, 50, 100, or 200 μg per kilogram of body weight) or placebo on days 1 and 56. Methods A systematic search was done using the Preferred Reporting Items for Mar 13, 2020 · Background: We performed a meta-analysis of the efficacy and safety of stem cell therapy as a clinical treatment of knee osteoarthritis. 2 Because there is no known cure for or spontaneous remission of the disease, 2 therapeutic regimens must often address chronic symptom management. J Orthop Surg Res. Apr 12, 2023 · Federal clearance of the MISHA knee system clears the way for widespread adoption of the first new surgical treatment for osteoarthritis of the knee in decades. Design Systematic review of randomised controlled trials (RCTs). Dey , 4 and Siba P. 249 [ PubMed ] [ CrossRef ] [ Google Scholar ] Sep 9, 2021 · Introduction. Volunteers eligible to take part in a clinical trial will receive: Complementary health assessment, including Blood Cholesterol check, Feb 23, 2006 · A response according to the guidelines of the Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT–OARSI) was classified as an improvement Dec 13, 2021 · The excellent RESTORE trial has just been published in JAMA 1 – it was my most eagerly awaited publication of 2021. Jul 11, 2002 · When medical therapy fails to relieve the pain of osteoarthritis of the knee, arthroscopic lavage or débridement is often recommended. 1089/humc. Nov 2, 2023 · The study was a phase 2/3, four-arm parallel, multicenter, single-blind, randomized, controlled clinical trial with 480 patients with a diagnosis of knee osteoarthritis (Kellgren–Lawrence Objective Stem cell therapy is increasingly used for knee osteoarthritis (KOA). Data from previously conducted placebo-controlled clinical trials were normalized and collated. The efficacy and occurrence of adverse reactions from ibuprofen was The Osteoarthritis Clinical Trial Network (OA-CTN) is an assembly of the leading clinical investigators and research institutions developing infrastructure to accelerate scientific innovations to the patient community. 2023; 18 (422) doi: 10. Among all the studies on clinical trials from 2008 to 2015, seven studies involved the treatment of the symptoms associated with synovitis, mainly pain [33–37, 39, 41, 46]; four involved measures taken to relieve synovial effusion or inflammation [38, 43–45]; and three involved measures taken to improve This randomized trial assesses the effect of injections of platelet-rich plasma vs saline placebo on 12-month changes in knee pain scores and medial tibial cartilage volume among patients with symptomatic mild to moderate knee osteoarthritis. Lau , 2 Prachi Sharma , 1 Malkanthi Evans , 1 Najla Guthrie , 1 Manashi Bagchi , 2 Debasis Bagchi , 2, 3 Dipak K. Displaying 12 studies. Knee osteoarthritis (KOA) affects approximately 250 million people worldwide 1 and has a high societal and economic burden. 6, 7, 12, 40, 41 While osteoarthritis Oct 29, 2020 · McAlindon, T. More than 650,000 such procedures are performed each year 1 Apr 25, 2023 · The nonrandomized clinical trial leading to FDA approval compared the MISHA system with high tibial osteotomy (HTO) — an operation that adds or removes bone to shift weight from the damaged side of the knee joint. 1136/ard. Oct 9, 2009 · The present clinical trial evaluated the safety and efficacy of UC-II as compared to a combination of glucosamine and chondroitin (G+C) in the treatment of OA of the knee. , a biotech company developing Osteoarthritis Clinical Trials Do you suffer from knee pain caused by Osteoarthritis of the knee? Register your interest in our future clinical trials investigating potential medications to control knee pain taking place in the summer of 2023. J Transl Med. doi: 10. A randomized clinical trial published in 2017 compared intra- and periarticular 25% dextrose prolotherapy in fifty-two adults with knee osteoarthritis. Forty nine men and women 45-90 (mean 68 ± SD 7. 19, 32 – 39 Massage does not carry the adverse effects of many pharmacologic and invasive treatments. OHSU is among five centers involved in the nationwide clinical trial that validated the new approach, and expects to be able to offer the procedure routinely in the coming months. This was a Randomised Control Trial (RCT) of Platelet Rich Plasma (PRP) injections vs placebo saline for mild-moderate knee osteoarthritis (OA) with a protocol pre-published, high enrolment, good blinding and MRI pre- and post- assessment. Osteoarthritis Clinical Trials Do you suffer from knee pain caused by Osteoarthritis of the knee? Register your interest in our future clinical trials investigating potential medications to control knee pain taking place in the summer of 2023. Oct 5, 2018 · Introduction. Mar 1, 2006 · Conclusion. May 8, 2022 · The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial. - Active synovial inflammation at screening (defined a summary score of ≥7 with at least one region scoring 2) on contrast enhanced MRI (CE-MRI) of the whole knee for synovitis detection from 11 sites. Nov 29, 2022 · UCI Health and the UCI Alpha Clinic have launched the first U. Non-steroidal antiinflammatory drugs (NSAIDs) are being used for the treatment of osteoarthritis. clinical trial to test the safety and tolerability of a stem cell therapy for patients with muscle atrophy related to knee osteoarthritis. Apr 12, 2023 · OHSU clinical trial validates this week’s FDA approval of implantable shock absorber; marks first new surgical treatment in decades for osteoarthritis of the knee. Dec 12, 2018 · Effect sizes were large in the present study and were comparable to, or superior to, those seen in other trials conducted using non-pharmacological approaches in patients with knee osteoarthritis. MSM (3. 125 The study aim is to conduct a clinical research investigation to compare two alignment techniques used in contemporary total knee arthroplasty by means of a prospective non-randomized clinical trial. Jan 27, 2016 · Thus, oral HA can relieve knee pain. 107805. Gene Ther. Subjects in massage or Apr 8, 2020 · Some clinical trials of treatments for osteoarthritis of the knee have suggested that physical therapy confers short-term and long-term relief of symptoms, functional improvement, and a Mar 2, 2021 · Osteoarthritis (OA) is one of the most prevalent chronic joint diseases, a leading cause of chronic pain and disability 30 that affects an estimated 25% of adults aged 55 years or older. Jun 27, 2011 · Methods. gov NCT01453738 . Efficacy and safety of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (Stempeucel®): preclinical and clinical trial in osteoarthritis of the knee joint The outcomes of interest in this review are those recommended by the Outcome Measures in Rheumatology and Arthritis Clinical Trials guidelines 29 and the Osteoarthritis Research Society task force on clinical trials 30 as core, or primary, outcomes for osteoarthritis trials: pain, physical function, and patient global assessment. May 31, 2022 · Several studies have also been conducted to determine if the injection method of dextrose prolotherapy could have an impact on the effectiveness of prolotherapy in knee osteoarthritis. JAMA 317 , 1967 Apr 21, 2022 · These searches were performed using the following keywords: “acupuncture,” “electroacupuncture,” Knee osteoarthritis,” “KOA,” “Osteoarthritis of knee,” “Randomized controlled trials,” and “RCT,” and two reviewers (HT and LY H) first screened the literature by scanning the titles and abstracts and then read the full Oct 9, 2009 · Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial David C. Osteoarthritis is the most common type of arthritis and a very important cause of disability; therefore, clinical trials are often carried out to discover a way to cure it, and to test out new treatments meant to improve the quality of life of those who suffer from it. Primary osteoarthritis is articular degeneration without any apparent underlying reason. Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice. The purpose of the present study was to systematically review the clinical and functional outcomes following mesenchymal stem cell application focusing on early to moderate knee osteoarthritis. Dr. 249 [ PubMed ] [ CrossRef ] [ Google Scholar ] Dec 20, 2016 · Clinicaltrials. 2010; 69 (2):374–379. Jul 17, 2020 · Karimifar M, Soltani R, Hajhashemi V, et al. This open multicenter trial investigated the safety and efficacy of an Arnica montana fresh plant gel, applied twice daily, in 26 men and 53 women with mild to moderate osteoarthritis (OA) of the knee. The benefits of HTO last eight to 10 years, and the surgery is not considered a permanent stand-in for knee replacement. Evaluation of the effect of Elaeagnus angustifolia alone and combined with Boswellia thurifera compared with ibuprofen in patients with knee osteoarthritis: a randomized double-blind controlled clinical trial. 1186/s13018-023-03891-6. For those who want to avoid replacing the entire knee joint, there may soon be another option that could help patients get back on their feet fast, pain-free, and stay that way. Eligibility criteria RCTs evaluating autologous mesenchymal stem cell (MSC) therapy on patient-reported outcome measures and Apr 21, 2022 · These searches were performed using the following keywords: “acupuncture,” “electroacupuncture,” Knee osteoarthritis,” “KOA,” “Osteoarthritis of knee,” “Randomized controlled trials,” and “RCT,” and two reviewers (HT and LY H) first screened the literature by scanning the titles and abstracts and then read the full Apr 26, 2022 · Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: long-term follow up of a multicenter randomized controlled clinical trial (phase I/II) Lamo-Espinosa JM, Mora G, Blanco JF, et al. g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events. 3, 4 Elderly (approximately 35% of patients over 65 years old) females, patients with obesity and African Americans are the Osteoarthritis Clinical Trials. Sep 21, 2020 · Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: long-term follow up of a multicenter randomized controlled clinical trial (phase I/II) Lamo-Espinosa JM, Mora G, Blanco JF, et al. Ann Rheum Dis. aogpyjxcpqxgjaqmgcecudmeinzwkwdiwdvhmnxuwqtnjtnjjhwc
Clinical trials for osteoarthritis of the knee. Forty nine men and women 45-90 (mean 68 ± SD 7.
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